The three‐dimensional structure of the 50S ribosomal subunit ( 6, 7) has shown that in protein synthesis, RNA, rather than protein, catalyzes peptide bond formation. The biological significance of RNA is reflected in the large number of systems in which RNA plays a key role, in particular the numerous examples of RNA with catalytic activity ( 4, 5). Although the number of three‐dimensional RNA structures currently available is small when compared with the number of protein structures, it is still substantial, and the complexity of RNA structures is comparable with that of proteins. The structural and evolutionary classifications of proteins, publicly available in the SCOP ( 1), CATH ( 2) and FSSP ( 3) databases, have been key to our understanding of protein structure. Received as resubmission FebruAccepted MaINTRODUCTION
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